ea0031oc3.3 | Reproduction, growth and development | SFEBES2013
Jonas Kim
, Muller Adolfo Rivero
, Chou Yen Yin
, Ji Tae
, Hanyaloglu Aylin
Accepted dogma once stated that G protein-coupled receptors (GPCRs) function as monomers, however, over the last decade in vitro experiments have shown GPCRs to function as dimers and higher order oligomers. We have recently reported the first in vivo evidence for the physiological importance of Class A GPCR homodimerisation using the LHCGR as a model receptor. Transgenic co-expression of binding deficient LHCGR (LHCGR-LH) and signalling deficient ...